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验证数据展示

  • WB analysis of human brain using 10242-1-AP (same clone as 10242-1-PBS)

    WB analysis of human brain using 10242-1-AP (same clone as 10242-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP (CYC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

    IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CYC1 antibody included
  • IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

    IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CYC1 antibody included
  • Featured Product
  • KD/KO Validated

CYC1 Polyclonal antibody, PBS Only

CYC1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 10242-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy CYC1 Ready-To-Use IHC Kit. CYC1 primary antibody included.

产品信息

10242-1-PBS targets CYC1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag0291

Product name: Recombinant human CYC1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 46-271 aa of BC001006

Sequence: ALSSKSGLSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVC

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 cytochrome c-1
别名
计算分子量 35 kDa
观测分子量 35 kDa
GenBank蛋白编号BC001006
基因名称 CYC1
Gene ID (NCBI) 1537
RRIDAB_2090144
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP08574
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CYC1, also named as Cytochrome c-1, belongs to the cytochrome c family. Cytochrome c1 is one respiratory subunit of the 11 subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c(PMID:3036122 ). CYC1 mediates apoptosis. In this pathway, a variety of apoptotic stimuli cause CYC1 release from mitochondria, which in turn induces a series of biochemical reactions that result incaspase activation and subsequent cell death.(PMID:15189137) While CYC1 release and DNA fragmentation are unaffected by the noncleavablep75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed(PMID:15186778). The protein migrated as a 35 kd band in SDS page.

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