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验证数据展示

  • IF Staining of human tonsillitis using 60065-1-Ig (same clone as 60065-1-PBS)

    IF Staining of human tonsillitis using 60065-1-Ig (same clone as 60065-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using CXCR3B-specific antibody (60065-1-Ig, Clone: 1B2D6 ) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 594-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM004). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60065-1-PBS in a different storage buffer formulation.

  • WB analysis of MOLT-4 using 60065-1-Ig (same clone as 60065-1-PBS)

    WB analysis of MOLT-4 using 60065-1-Ig (same clone as 60065-1-PBS)

    MOLT-4 cells were subjected to SDS PAGE followed by western blot with 60065-1-Ig (CXCR3B-specific antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60065-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 60065-1-Ig (same clone as 60065-1-PBS)

    IHC staining of human tonsillitis using 60065-1-Ig (same clone as 60065-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 60065-1-Ig (CXCR3B-specific antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60065-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 60065-1-Ig (same clone as 60065-1-PBS)

    IHC staining of human tonsillitis using 60065-1-Ig (same clone as 60065-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 60065-1-Ig (CXCR3B-specific antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60065-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

CXCR3B-specific Monoclonal antibody, PBS Only

CXCR3B-specific Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 60065-1-PBS

产品说明书

CloneNo. 1B2D6

宿主/亚型

Mouse / IgG2b

种属反应性

human

应用

WB, IHC, IF-P, Indirect ELISA

别名

CXCR3, CMKAR3, CKR-L2, CKR L2, CD183

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

60065-1-PBS targets CXCR3B-specific in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 chemokine (C-X-C motif) receptor 3
别名 CXCR3, CMKAR3, CKR-L2, CKR L2, CD183
计算分子量 46 kDa
观测分子量43 kDa
GenBank蛋白编号AF469635
基因名称 CXCR3
Gene ID (NCBI) 2833
RRIDAB_2292376
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP49682
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4 (PMID:12782716). This monoclonal antibody is specific to CXCR3B.