验证数据展示
产品信息
67555-1-PBS targets CRX in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | Human, mouse, rat, pig |
免疫原 | CRX fusion protein Ag30086 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | cone-rod homeobox |
别名 | cone rod homeobox, Cone rod homeobox protein, CORD2, CRD, CRX, LCA7, OTX3 |
计算分子量 | 299 aa, 32 kDa |
观测分子量 | 37 kDa |
GenBank蛋白编号 | BC016664 |
基因名称 | CRX |
Gene ID (NCBI) | 1406 |
RRID | AB_2882769 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | O43186 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Cone-rod homeobox (Crx) is a homeodomain transcription factor and member of the Otx family, which has been thought to play a critical role in determining and maintaining the phenotype of both pinealocytes and retinal photoreceptors [PMID:17467693]. In the mammalian retina, Crx plays an essential role in the normal development and maintenance of cones and rods and regulates expression of the network of genes that characterize the retina [PMID:17653270]. Elimination of Crx by disruption of the homeobox domain results in loss of the image-forming visual system but not the non-image-forming visual system controlling circadian rhythms [PMID:20438719].