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验证数据展示

  • WB analysis of Jurkat using 11275-1-AP (same clone as 11275-1-PBS)

    WB analysis of Jurkat using 11275-1-AP (same clone as 11275-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 11275-1-AP (CREB3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 11275-1-AP (same clone as 11275-1-PBS)

    WB analysis of HeLa using 11275-1-AP (same clone as 11275-1-PBS)

    WB result of CREB3 antibody (11275-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-CREB3 transfected HeLa cells. This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 11275-1-AP (same clone as 11275-1-PBS)

    IF Staining of U2OS using 11275-1-AP (same clone as 11275-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using CREB3 antibody (11275-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

CREB3 Polyclonal antibody, PBS Only

CREB3 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 11275-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy CREB3 Ready-To-Use IHC Kit. CREB3 primary antibody included.

产品信息

11275-1-PBS targets CREB3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag1823

Product name: Recombinant human CREB3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-371 aa of BC009402

Sequence: MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTCILVLLVSFCLLLVPAIYSSDTRGSLPAEHGVLSRQLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 cAMP responsive element binding protein 3
别名
计算分子量 44 kDa
观测分子量 40-64 kDa
GenBank蛋白编号BC009402
基因名称 CREB3
Gene ID (NCBI) 10488
RRIDAB_10640533
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO43889
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CREB3, also named as LZIP and Luman, belongs to the bZIP family and ATF subfamily. It is a transcription factors activated upon intramembrane proteolysis (RIP), binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. CREB3 binds to and requires HCFC1 as a coactivator. The activity and expression are suppressed when the HCFC1-CREB3 complex binds with CREBZF. Participates in LKN-1/CCL15-induced chemotaxis signaling. CREB3 is N-glycosylated and released by proteolysis. So the MW of CREB3 emirate 40kd to 64kd (PMID: 12138176).

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