验证数据展示
产品信息
66849-1-PBS targets CPLX2 in WB, IHC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
| 经测试应用 | WB, IHC, FC (Intra), Indirect ELISA Application Description | 
| 经测试反应性 | human, mouse, rat, pig | 
| 免疫原 | CatNo: Ag27949 Product name: Recombinant human CPLX2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-134 aa of BC093706 Sequence: MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTVLKYLPGPLQDMFKK种属同源性预测 | 
| 宿主/亚型 | Mouse / IgG1 | 
| 抗体类别 | Monoclonal | 
| 产品类型 | Antibody | 
| 全称 | complexin 2 | 
| 别名 | CPX 2, CPLX 2, Complexin-2, 921L, 921 L | 
| 计算分子量 | 134 aa, 15 kDa | 
| 观测分子量 | 18-20 kDa | 
| GenBank蛋白编号 | BC093706 | 
| 基因名称 | CPLX2 | 
| Gene ID (NCBI) | 10814 | 
| RRID | AB_2882189 | 
| 偶联类型 | Unconjugated | 
| 形式 | Liquid | 
| 纯化方式 | Protein G purification | 
| UNIPROT ID | Q6PUV4 | 
| 储存缓冲液 | PBS only, pH 7.3. | 
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C | 
背景介绍
Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Neuronal specific complexin 1 (CPLX1) has inhibitory and stimulatory effects on exocytosis by clamping trans-SNARE complexes in a prefusion state and promoting conformational changes to facilitate membrane fusion following cell stimulation. Complexin2 (CPLX2) is a pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals, it is downregulated in schizophrenic patients suffering from depression, animal models of depression and neurological disorders such as Huntington's disease in which depression is a major symptom.







