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验证数据展示

  • WB analysis using 84151-4-RR (same clone as 84151-4-PBS)

    WB analysis using 84151-4-RR (same clone as 84151-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84151-4-RR (COX-1/Cyclooxygenase-1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84151-4-PBS in a different storage buffer formulation.

  • WB analysis of THP-1 using 84151-4-RR (same clone as 84151-4-PBS)

    WB analysis of THP-1 using 84151-4-RR (same clone as 84151-4-PBS)

    THP-1 cells were subjected to SDS PAGE followed by western blot with 84151-4-RR (COX-1/Cyclooxygenase-1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84151-4-PBS in a different storage buffer formulation.

  • IHC staining of mouse stomach using 84151-4-RR (same clone as 84151-4-PBS)

    IHC staining of mouse stomach using 84151-4-RR (same clone as 84151-4-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse stomach tissue slide using 84151-4-RR (COX-1/Cyclooxygenase-1 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84151-4-PBS in a different storage buffer formulation.

  • IHC staining of mouse stomach using 84151-4-RR (same clone as 84151-4-PBS)

    IHC staining of mouse stomach using 84151-4-RR (same clone as 84151-4-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse stomach tissue slide using 84151-4-RR (COX-1/Cyclooxygenase-1 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84151-4-PBS in a different storage buffer formulation.

  • IF Staining of C2C12 using 84151-4-RR (same clone as 84151-4-PBS)

    IF Staining of C2C12 using 84151-4-RR (same clone as 84151-4-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed C2C12 cells using COX-1/Cyclooxygenase-1 antibody (84151-4-RR, Clone: 241373C10 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84151-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84151-4-RR

    Affinity and Kinetic Characterization of 84151-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84151-4-RR against Human COX-1/Cyclooxygenase-1 were performed. The affinity constant is below 1 pM.

COX-1/Cyclooxygenase-1 Recombinant monoclonal antibody, PBS Only

COX-1/Cyclooxygenase-1 Uni-rAb® Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 84151-4-PBS

产品说明书

CloneNo. 241373C10

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

PGH1, PTGS1, 241373C10, COX1, Cyclooxygenase-1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84151-4-PBS targets COX-1/Cyclooxygenase-1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4055

Product name: Recombinant human PTGS1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 250-599 aa of BC029840

Sequence: KLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
别名 PGH1, PTGS1, 241373C10, COX1, Cyclooxygenase-1
计算分子量 599 aa, 69 kDa
观测分子量 60-72 kDa
GenBank蛋白编号BC029840
基因名称 PTGS1
Gene ID (NCBI) 5742
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP23219
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTGS1(Prostaglandin G/H synthase 1) belongs to the prostaglandin G/H synthase family and catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. It is also named as COX1(Cyclooxygenase-1). There is no PTGS1 expression in fetal samples (prostate, seminal vesicles, or ejaculatory ducts), and only minimal expression in adult tissues (PMID: 10999846). PTGS1 has some isoforms with MW of 56-72 kD and PTGS1 can form homodimer.

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