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验证数据展示

  • WB analysis of rat heart using 83566-1-RR (same clone as 83566-1-PBS)

    WB analysis of rat heart using 83566-1-RR (same clone as 83566-1-PBS)

    rat heart tissue were subjected to SDS PAGE followed by western blot with 83566-1-RR (CORIN antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83566-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 83566-1-RR (same clone as 83566-1-PBS)

    IHC staining of mouse heart using 83566-1-RR (same clone as 83566-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 83566-1-RR (CORIN antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83566-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 83566-1-RR (same clone as 83566-1-PBS)

    IHC staining of mouse heart using 83566-1-RR (same clone as 83566-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 83566-1-RR (CORIN antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83566-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83566-1-RR

    Affinity and Kinetic Characterization of 83566-1-RR

    Biolayer interferometry (BLl) kinetic assays of 83566-1-RR against Human CORIN were performed. The affinity constant is below 1 pM.

CORIN Recombinant monoclonal antibody, PBS Only

CORIN Uni-rAb® Recombinant Antibody for WB, IHC, ELISA
Cat No. 83566-1-PBS

产品说明书

CloneNo. 240339A10

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, ELISA

别名

TMPRSS10, serine peptidase, CRN, 240339A10

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

83566-1-PBS targets CORIN in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag15898

Product name: Recombinant human CORIN protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 551-900 aa of BC110451

Sequence: WPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 corin, serine peptidase
别名 TMPRSS10, serine peptidase, CRN, 240339A10
计算分子量 1042 aa, 117 kDa
GenBank蛋白编号BC110451
基因名称 CORIN
Gene ID (NCBI) 10699
RRIDAB_3671181
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ9Y5Q5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CORIN is a transmembrane type II serine protease expressed in cardiomyocytes that converts pro-atrial natriuretic peptide into atrial natriuretic peptide, a cardiac hormone that regulates blood pressure. CORIN can be shed into the circulation through autocleavage and metalloproteinase-mediated hydrolysis processes of the membrane form of the protein. Three different soluble fragments derived from corin molecules, with molecular masses of ~180, ~160 and ~100 kDa were described in literature (PMID: 21288900, 29387201).

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