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验证数据展示

  • WB analysis of mouse brain using 10464-1-AP (same clone as 10464-1-PBS)

    WB analysis of mouse brain using 10464-1-AP (same clone as 10464-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 10464-1-AP (COPS4 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.

  • IP experiment of PC-3 using 10464-1-AP (same clone as 10464-1-PBS)

    IP experiment of PC-3 using 10464-1-AP (same clone as 10464-1-PBS)

    IP result of anti-COPS4 (IP:10464-1-AP, 4ug; Detection:10464-1-AP 1:300) with PC-3 cells lysate 1800ug. This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 10464-1-AP (same clone as 10464-1-PBS)

    IHC staining of human placenta using 10464-1-AP (same clone as 10464-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 10464-1-AP (COPS4 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10464-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with COPS4 antibody included

COPS4 Polyclonal antibody, PBS Only

COPS4 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 10464-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

COPS, COPS 4, CSN4, JAB1 containing signalosome subunit 4, JAB1-containing signalosome subunit 4

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy COPS4 Ready-To-Use IHC Kit. COPS4 primary antibody included.

产品信息

10464-1-PBS targets COPS4 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag0735

Product name: Recombinant human COPS4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-250 aa of BC004302

Sequence: MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
别名 COPS, COPS 4, CSN4, JAB1 containing signalosome subunit 4, JAB1-containing signalosome subunit 4
计算分子量 46 kDa
观测分子量 40 kDa, 46 kDa
GenBank蛋白编号BC004302
基因名称 COPS4
Gene ID (NCBI) 51138
RRIDAB_2081630
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BT78
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an ess ential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. CSN4 gene encodes a component of CSN complex, COP9 signalosome complex subunit 4 (COPS4). The ubiquitin-proteasome system plays a major role in the rhythmic accumulation and turnover of molecular clock components. A recent study in Drosophila indicates that CSN lie in a common pathway leading to light-dependent degradation of clock protein Timeless (TIM).

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