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验证数据展示

  • IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

    IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

    IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse liver using 15039-1-AP (same clone as 15039-1-PBS)

    IP experiment of mouse liver using 15039-1-AP (same clone as 15039-1-PBS)

    IP result of anti-CMTM8 (IP:15039-1-AP, 4ug; Detection:15039-1-AP 1:300) with mouse liver tissue lysate 6800ug. This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse bladder using 15039-1-AP (same clone as 15039-1-PBS)

    WB analysis of mouse bladder using 15039-1-AP (same clone as 15039-1-PBS)

    mouse bladder tissue were subjected to SDS PAGE followed by western blot with 15039-1-AP (CMTM8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

CMTM8 Polyclonal antibody, PBS Only

CMTM8 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 15039-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

Chemokine-like factor superfamily member 8, CKLF-like MARVEL transmembrane domain-containing protein 8, CKLFSF8

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

15039-1-PBS targets CMTM8 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag6776

Product name: Recombinant human CMTM8 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-173 aa of BC041390

Sequence: MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 CKLF-like MARVEL transmembrane domain containing 8
别名 Chemokine-like factor superfamily member 8, CKLF-like MARVEL transmembrane domain-containing protein 8, CKLFSF8
计算分子量 20 kDa
观测分子量 25-28 kDa
GenBank蛋白编号BC041390
基因名称 CMTM8
Gene ID (NCBI) 152189
RRIDAB_10949191
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8IZV2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CMTM8, also known as CKLFSF8, is a member of the chemokine-like factor superfamily (CKLFSF). Proteins of this family share similarity with both the chemokine and the transmembrane 4 superfamilies. CMTM8 is an attenuator of EGF-induced signaling (PMID: 16263120). Overexpression of CMTM8 accelerates ligand-induced clearance of EGFR from the cell surface and induces apoptosis via caspase-dependent and -independent pathways (PMID: 17149703). An alternative splice form of CMTM8, CMTM8-v2, arises from a deletion of exon 2. CMTM8-v2 maintains the ability to induce apoptosis (PMID: 17681841).

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