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验证数据展示

  • WB analysis using 25877-1-AP (same clone as 25877-1-PBS)

    WB analysis using 25877-1-AP (same clone as 25877-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25877-1-AP (CMPK2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25877-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 25877-1-AP (same clone as 25877-1-PBS)

    IHC staining of human lung cancer using 25877-1-AP (same clone as 25877-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 25877-1-AP (CMPK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25877-1-PBS in a different storage buffer formulation.

CMPK2 Polyclonal antibody, PBS Only

CMPK2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 25877-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

EC:2.7.4.14, EC:2.7.4.6, Nucleoside-diphosphate kinase, TYKi, UMP CMPK2

缓冲液配方: 
偶联物:  Unconjugated
规格价格库存

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产品信息

25877-1-PBS targets CMPK2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag22885

Product name: Recombinant human CMPK2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-346 aa of BC141802

Sequence: MAFARRLLRGPLSGPLLGRRGVCAGAMAPPRRFVLELPDCTLAHFALGADAPGDADAPDPRLAALLGPPERSYSLCVPVTPDAGCGARVRAARLHQRLLHQLRRGPFQRCQLLRLLCYCPGGQAGGAQQGFLLRDPLDDPDTRQALLELLGACQEAPRPHLGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVPEPPLHPVVPDLPSSVVFPDREAARAVLEECTSFIPEARAVLDLVDQCPKQIQKGKFQVVAIEGLDATGKTTVTQSVADSLKAVLLKSPPSCIGQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESAKSPVIVDRYWHSTATYAIATEVS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
别名 EC:2.7.4.14, EC:2.7.4.6, Nucleoside-diphosphate kinase, TYKi, UMP CMPK2
计算分子量 449 aa, 49 kDa
观测分子量 55 kDa
GenBank蛋白编号BC141802
基因名称 CMPK2
Gene ID (NCBI) 129607
RRIDAB_3085825
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ5EBM0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CMPK2 belongs to the thymidylate kinase family. CMPK2 may participate in dUTP and dCTP synthesis in mitochondria. It is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy of CMPK2 is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. CMPK2 may be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.

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