验证数据展示
产品信息
83522-5-PBS targets CKB in WB, FC (Intra), ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, FC (Intra), ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | CKB fusion protein Ag7285 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | creatine kinase, brain |
别名 | KCRB, 240418D2, B CK, B-CK, CKBB |
计算分子量 | 43 kDa |
观测分子量 | 40-45 kDa |
GenBank蛋白编号 | BC001190 |
基因名称 | CKB |
Gene ID (NCBI) | 1152 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | P12277 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CKBB, also named as B-CK and CKB, is a member of the ATP:guanido phosphotransferase protein family. It is a cytoplasmic enzyme involved in energy homeostasis. CKBB reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. CK isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. CK MB consists of a dimer of nonidentical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. This antibody can recognize both CKB and CKM due to the high homology.