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验证数据展示

  • WB analysis using 86474-3-RR (same clone as 86474-3-PBS)

    WB analysis using 86474-3-RR (same clone as 86474-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86474-3-RR (CHMP6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86474-3-PBS in a different storage buffer formulation.

  • IF Staining of U-937 using 86474-3-RR (same clone as 86474-3-PBS)

    IF Staining of U-937 using 86474-3-RR (same clone as 86474-3-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U-937 cells using CHMP6 antibody (86474-3-RR, Clone: 251259C5 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86474-3-PBS in a different storage buffer formulation.

  • Affinity of 86474-3-RR

    Affinity of 86474-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86474-3-RR against Human CHIMP6 were performed. The affinity constant is 0.148 nM.

CHMP6 Recombinant monoclonal antibody, PBS Only

CHMP6 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86474-3-PBS

产品说明书

CloneNo. 251259C5

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

chromatin modifying protein 6, Chromatin-modifying protein 6, hVps20, Vacuolar protein sorting-associated protein 20, Vps20

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86474-3-PBS targets CHMP6 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag9357

Product name: Recombinant human CHMP6 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-201 aa of BC010108

Sequence: MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERERALARQLLRDGRKERAKLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQFGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEELSAITQEQIELPEVPSEPLPEKIPENVPVKARPRQAELVAAS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 chromatin modifying protein 6
别名 chromatin modifying protein 6, Chromatin-modifying protein 6, hVps20, Vacuolar protein sorting-associated protein 20, Vps20
计算分子量 201 aa, 23 kDa
观测分子量 28-30 kDa
GenBank蛋白编号BC010108
基因名称 CHMP6
Gene ID (NCBI) 79643
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ96FZ7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CHMP6 (charged multivesicular body protein 6) is a protein that plays a significant role in the formation of multivesicular bodies (MVBs) within cells. It is a component of the endosomal sorting complex required for transport III (ESCRT-III), which is involved in the sorting and transport of proteins within the cell. CHMP6 has been identified as a novel prognostic biomarker in bladder cancer, where it enhances cell survival and migration by regulating the cell cycle. (PMID: 40630215)

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