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CFLAR/FLIP Polyclonal antibody, PBS Only

CFLAR/FLIP Polyclonal Antibody for WB, IHC, IF/ICC, IP, ELISA
Cat No. 10394-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, IP, ELISA

CFLAR, c FLIP, c FLIPL, c FLIPR, c FLIPS

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存


Planning an IHC experiment? We recommend our IHCeasy CFLAR/FLIP Ready-To-Use IHC Kit. CFLAR/FLIP primary antibody included.

产品信息

10394-1-PBS targets CFLAR/FLIP in WB, IHC, IF/ICC, IP, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, IP, ELISA Application Description
经测试反应性 human, mouse
免疫原 CFLAR/FLIP fusion protein Ag0593 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 CASP8 and FADD-like apoptosis regulator
别名 CFLAR, c FLIP, c FLIPL, c FLIPR, c FLIPS
计算分子量 52 kDa
观测分子量 20-35 kDa, 50-55 kDa
GenBank蛋白编号BC001602
基因名称 FLIP
Gene ID (NCBI) 8837
RRIDAB_2081087
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO15519
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CFLAR, also named as CASH, CASP8AP1, CLARP, MRIT, Casper, c-FLIP and I-FLICE, belongs to the peptidase C14A family. It is an apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. CFLAR acts as an inhibitor of TNFRSF6 mediated apoptosis. It can be cleaved to be 2 fragments P43 and P12. P43 is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.

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