验证数据展示
产品信息
33231-1-PBS targets CDY1B in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag37962 Product name: Recombinant human CDY1B protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 65-300 aa of BC132929 Sequence: LTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDKHHRSKNRKLFAASKNVRRKAASILSDTKNMEIINSTIETLAPDSPFDHKTVSGFQKLEKLDPIAADQQDTVVFKVTEGKLLRDPLSRPGAEQTGIQNKTQIHPLMSQMSGSVTASMATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGGQRNITDDSRDQPFIKKMHFTIRLTESASTYRDIVVKKEDGFTQIVLS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | chromodomain protein, Y-linked, 1B |
| 别名 | CDY1, CDY1A, EC:2.3.1.48, Testis-specific chromodomain protein Y 1 |
| 计算分子量 | 540 aa, 60 kDa/554 aa, 62 kDa |
| 观测分子量 | 65 kDa |
| GenBank蛋白编号 | BC132929 |
| 基因名称 | CDY1B |
| Gene ID (NCBI) | 253175 |
| RRID | AB_3742906 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q9Y6F8 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The CDY1B gene, also known as Chromodomain Y-Linked 1B, is a Protein Coding gene located on the Y chromosome. It is one of the two identical copies of the CDY1 gene within the AZFc region of the human Y chromosome. As a histone acetyltransferase, CDY1B exhibits a strong preference for histone 4, suggesting its involvement in both spermatogenic histone replacement and DNA transcription. It plays a significant role in the chromatin remodeling of round spermatid nuclei, contributing to the transition from histone-based chromatin to protamine-based chromatin during spermatogenesis. This transition is essential for the condensation of sperm DNA and the formation of mature sperm. Deletion of either CDY1 can lead to spermatogenic failure and male infertility.
