验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IF | See 1 publications below |
产品信息
20061-1-AP targets CDK5RAP2-Specific in WB, IF, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human |
| 文献引用反应性 | human |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | CDK5 regulatory subunit associated protein 2 |
| 别名 | C48, CDK5RAP2, Cep215, KIAA1633, MCPH3 |
| 计算分子量 | 215 kDa |
| GenBank蛋白编号 | NM_001011649 |
| 基因名称 | CDK5RAP2 |
| Gene ID (NCBI) | 55755 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q96SN8 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CDK5RAP2, also named as CEP215 and KIAA1633, belongs to the methylthiotransferase family and MiaB subfamily. This protein binds to p25NCK5A and therefore may be involved in neuronal differentiation. It may also be a substrate of neuronal CDC2-like kinase. CDK5RAP2 specifically inhibits CDK5 activation by CDK5R1. Defects in CDK5RAP2 are the cause of primary microcephaly autosomal recessive type 3 (MCPH3). Multiple isoforms generated through co- and/or posttranslational modifications or degradation may exist as scientists have described bands of 70, 90, 105, 200, and 230 kDa in mice depending on the age and organ investigated as well as the anti-Cdk5rap2 antibody applied or 210kd in total cell lysates of some human canser cell lines. (PUMID: 21327915, 20471352 and 18042621). The antibody is specific to CDK5RAP2.