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CDK10 Polyclonal antibody

CDK10 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, ELISA and More (1)

Conjugate

Unconjugated

Cat No : 17182-1-AP

Print datasheet

Synonyms

CDK10, cyclin dependent kinase 10, PISSLRE

验证数据展示

  • IHC staining of mouse brain using 17182-1-AP

    IHC staining of mouse brain using 17182-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 17182-1-AP (CDK10 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of mouse brain using 17182-1-AP

    IHC staining of mouse brain using 17182-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 17182-1-AP (CDK10 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive IHC detected inmouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

发表文章中的应用

WBSee 1 publications below

产品信息

17182-1-AP targets CDK10 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IHC, ELISA
Cited ApplicationsWB
Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Immunogen CDK10 fusion protein Ag10935 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name cyclin-dependent kinase 10
Synonyms CDK10, cyclin dependent kinase 10, PISSLRE
Calculated Molecular Weight 283 aa, 32 kDa
Observed Molecular Weight 38 kDa
GenBank Accession NumberBC017342
Gene Symbol CDK10
Gene ID (NCBI) 8558
RRIDAB_2878356
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ15131
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Cyclin-dependent kinase 10 (CDK10) is a Cdc2-related kinase that was discovered based on its homology to the Cdc2 PSTA1RE amino acid domain (PMID: 8208557). CDK10 plays a pivotal role in the regulation of fundamental cellular processes, including cell proliferation, transcription regulation, and cell cycle regulation. It partners with cyclin M to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth. Initial reports have indicated that CDK10 may act as a tumor suppressor in breast cancer (PMID: 26392360). Additional studies have demonstrated tumor suppressive and oncogenic roles for CDK10 in malignancies such as hepatobiliary cancers, gastric cancer, glioma, nasopharyngeal carcinoma, and colorectal cancer(PMID: 22326270,PMID: 29512714, PMID: 23740091, PMID: 29845196)

实验方案

Product Specific Protocols
IHC protocol for CDK10 antibody 17182-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Oncol Lett

miR-433 accelerates acquired chemoresistance of gallbladder cancer cells by targeting cyclin M.

Authors - Jianhua Yu
View Article