验证数据展示
65224-1-Ig
产品信息
65224-1-PBS targets CD86 in FC applications and shows reactivity with rat samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | rat |
| 免疫原 |
HTLV-1-transformed Lewis-S1 rat T cell line 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | CD86 molecule |
| 别名 | B7 2, B7-2, CD86 molecule |
| 计算分子量 | 36 kDa |
| GenBank蛋白编号 | NM_020081 |
| 基因名称 | Cd86 |
| Gene ID (NCBI) | 56822 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | O35531 |
| 储存缓冲液 | PBS Only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CD86 (also known as B7.2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response.
