验证数据展示
65253-1-Ig
产品信息
65253-1-PBS targets CD64 in FC applications and shows reactivity with human, monkey, non-human primates samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | human, monkey, non-human primates |
| 免疫原 |
Human rheumatoid synovial fluid cells and fibronectin-purified monocytes. 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
| 别名 | CD64A, Fc gamma RI, Fc gamma RIA, FCG1, Fc-gamma RI |
| 计算分子量 | 374 aa, 43 kDa |
| GenBank蛋白编号 | BC032634 |
| 基因名称 | FCGR1A |
| Gene ID (NCBI) | 2209 |
| ENSEMBL Gene ID | ENSG00000150337 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P12314 |
| 储存缓冲液 | PBS Only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Fcγ receptor comprise a multigene family of integral membrane glycoproteins that exhibit complex activation or inhibitory effects on cell functions after aggregation by complexed immunoglobulin G (IgG) (PMID: 17005690 ). CD64, also known as FcγRIA, is a high-affinity receptor for the Fc region of IgG. It is expressed by monocytes/macrophages, activated neutrophils, dendritic cells, and early myeloid cells (PMID: 23293080; 19642859; 7680917). CD64 functions in both innate and adaptive immune responses.
