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验证数据展示

  • WB analysis using 87503-1-RR (same clone as 87503-1-PBS)

    WB analysis using 87503-1-RR (same clone as 87503-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87503-1-RR (ITA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87503-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse colon using 87503-1-RR (same clone as 87503-1-PBS)

    IHC staining of mouse colon using 87503-1-RR (same clone as 87503-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 87503-1-RR (CD49b antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87503-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse colon using 87503-1-RR (same clone as 87503-1-PBS)

    IHC staining of mouse colon using 87503-1-RR (same clone as 87503-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 87503-1-RR (CD49b antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87503-1-PBS in a different storage buffer formulation.

  • Affinity of 87503-1-RR

    Affinity of 87503-1-RR

    Biolayer interferometry (BLl) kinetic assays of 87503-1-RR against Mouse CD49b were performed. The affinity constant is 17.7 nM.

Mouse CD49b Recombinant monoclonal antibody, PBS Only

CD49b Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 87503-1-PBS

产品说明书

CloneNo. 252736G5

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Itga2, DX5, integrin alpha 2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87503-1-PBS targets CD49b in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg10475

Product name: Recombinant mouse ITA2 protein

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-Twin-Strep-Tag

Domain: 10011440 of

Sequence: \

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 integrin alpha 2
别名 Itga2, DX5, integrin alpha 2
观测分子量150-160 kDa
基因名称 CD49b
Gene ID (NCBI) 16398
RRIDAB_3745585
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ62469
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Integrins are a large family of α/β transmembrane receptors playing a key role in cell-cell interactions and cell adhesion to the extracellular matrix (PMID: 30374344). CD49b, also known as integrin alpha-2, is a 150 kDa transmembrane glycoprotein expressed on a wide variety of cell types including platelets, megakaryocytes, NK cells, NKT cells, neutrophils, and long-term activated T cells (PMID: 18802064; 2415516). Integrin alpha-2/beta-1 (also known as VLA-2) is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin (PMID: 2557634). It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

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