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验证数据展示

  • FC experiment of mouse splenocytes using 98113-1-RR (same clone as 98113-1-PBS)

    FC experiment of mouse splenocytes using 98113-1-RR (same clone as 98113-1-PBS)

    1x10^6 untreated or anti-CD3/CD28 treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody (98113-1-RR, Clone: 241012G10) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD4. Cells were not fixed. This data was developed using the same antibody clone with 98113-1-PBS in a different storage buffer formulation.

  • FC experiment of mouse splenocytes using 98113-1-RR (same clone as 98113-1-PBS)

    FC experiment of mouse splenocytes using 98113-1-RR (same clone as 98113-1-PBS)

    1x10^6 anti-CD3/CD28 treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody (98113-1-RR, Clone:241012G10) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody (98113-1-RR, Clone: 241012G10) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98113-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98113-1-RR

    Affinity and Kinetic Characterization of 98113-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98113-1-RR against Mouse CD30 Ligand/TNFSF8 were performed. The affinity constant is 0.342 nM.

Anti-Mouse CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody, PBS Only

CD30 Ligand/TNFSF8 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98113-1-PBS

产品说明书

CloneNo. 241012G10

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

Tnfsf8, Tumor necrosis factor ligand superfamily member 8, CD30-L, CD30 ligand, 241012G10

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98113-1-PBS targets CD30 Ligand/TNFSF8 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor (ligand) superfamily, member 8
别名 Tnfsf8, Tumor necrosis factor ligand superfamily member 8, CD30-L, CD30 ligand, 241012G10
计算分子量27 kDa
GenBank蛋白编号NM_009403.3
基因名称 Tnfsf8
Gene ID (NCBI) 21949
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP32972
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD30 Ligand (CD30L), also named as TNFSF8 or CD153, is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) superfamily (PMID: 8391931). It is expressed on the surface of activated T cells, B cells, monocytes, macrophages, eosinophils, neutrophils, and mast cells (PMID: 26090498). CD30L interacts with its receptor, CD30, which is a cell surface protein expressed on a small subset of activated T and B lymphocytes, and a variety of lymphoid neoplasms, with the highest expression in classical Hodgkin lymphoma and anaplastic large cell lymphomas (PMID: 28885612). The CD30/CD30L signaling is involved in pleiotropic downstream effects including differentiation, cell survival and death, NFkB activation, and production of cytokines (PMID: 38534788).