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验证数据展示

  • WB analysis using 86727-1-RR (same clone as 86727-1-PBS)

    WB analysis using 86727-1-RR (same clone as 86727-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86727-1-RR (Cd2ap antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86727-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 86727-1-RR (same clone as 86727-1-PBS)

    IHC staining of human kidney using 86727-1-RR (same clone as 86727-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 86727-1-RR (CD2AP antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86727-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 86727-1-RR (same clone as 86727-1-PBS)

    IHC staining of human kidney using 86727-1-RR (same clone as 86727-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 86727-1-RR (CD2AP antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86727-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86727-1-RR

    Affinity and Kinetic Characterization of 86727-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86727-1-RR against Mouse CD2AP were performed. The affinity constant is below 1 pM.

Mouse CD2AP Recombinant monoclonal antibody, PBS Only

CD2AP Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 86727-1-PBS

产品说明书

CloneNo. 251428G2

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

CD2 associated protein, CD2-associated protein, Mesenchyme-to-epithelium transition protein with SH3 domains 1, METS 1, Mets1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86727-1-PBS targets CD2AP in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag0622

Product name: Recombinant mouse Cd2ap protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-637 aa of BC157901

Sequence: MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERQGNVASLVQRISTYGLPAGGIQPHPQTKAIKKKTKKRQCKVLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTEDGETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDLSAAEKKAFPLKAEEKDEKSLLEQKPSKPAAPQVPPKKPTAPTKASNLLRSPGAVYPKRPEKPVPPPPPAAKINGEVSIISSKIDTEPVSKPKLDPEQLPVRPKSVDLDAFVARNSKETDDVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLKLPKEDDSGNLKPLEFKKDASYSSKPSLSTPSSASKVNTAAFLTPLELKAKAEADDGKKNSVDELRAQIIELLCIVDALKKDHGKELEKLRKELEEEKAMRSNLEVEIAKLKKAVLLS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD2-associated protein
别名 CD2 associated protein, CD2-associated protein, Mesenchyme-to-epithelium transition protein with SH3 domains 1, METS 1, Mets1
计算分子量 637 aa, 70 kDa
观测分子量74 kDa
GenBank蛋白编号BC157901
基因名称 Cd2ap
Gene ID (NCBI) 12488
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9JLQ0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD2 associated protein (CD2AP, also known as CMS) is a scaffolding molecule that acts as an adapter protein between membrane proteins and the actin cytoskeleton (PMID: 10339567). CD2AP also plays a role in epithelial cell junction formation and affects the pathogenesis of Alzheimer's disease (PMID: 22891260; 31440393). Its mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS) (PMID: 17713465; 19131354).

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