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验证数据展示

  • FC experiment of human monocyte-derived immature dendritic cells using 98017-1-RR (same clone as 98017-1-PBS)

    FC experiment of human monocyte-derived immature dendritic cells using 98017-1-RR (same clone as 98017-1-PBS)

    1x10^6 human monocyte-derived immature dendritic cells were surface stained with 0.25 ug Anti-Human B7-H3/CD276 Rabbit Recombinant Antibody (98017-1-RR, Clone: 230305A10) (red) or 0.25 ug Isotype Control(blue) and PE-conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98017-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98017-1-RR

    Affinity and Kinetic Characterization of 98017-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98017-1-RR against Human B7-H3/CD276 were performed. The affinity constant is 0.203 nM.

Anti-Human B7-H3/CD276 Rabbit Recombinant Antibody, PBS Only

B7-H3/CD276 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98017-1-PBS

产品说明书

CloneNo. 230305A10

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD276, B7-H3, B7H3, B7 homolog 3, B7 H3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98017-1-PBS targets B7-H3/CD276 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD276 molecule
别名 CD276, B7-H3, B7H3, B7 homolog 3, B7 H3
计算分子量57 kDa
GenBank蛋白编号NM_001024736
基因名称 CD276
Gene ID (NCBI) 80381
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ5ZPR3
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).