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Species Reactivity
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验证数据展示

  • FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

    FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

    1x10^6 untreated or PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD4 (RPA-T4) (APC-65143, Clone: RPA-T4). Cells were not fixed. This data was developed using the same antibody clone with 98181-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

    FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

    1x10^6 PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98181-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98181-1-RR

    Affinity and Kinetic Characterization of 98181-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98181-1-RR against Human CD134/OX40 were performed. The affinity constant is 5.48 nM.

Anti-Human CD134/OX40 Rabbit Recombinant Antibody, PBS Only

CD134/OX40 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98181-1-PBS

产品说明书

CloneNo. 241398G7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

TNFRSF4, OX40L receptor, OX40, CD134, ACT35 antigen

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98181-1-PBS targets CD134/OX40 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 4
别名 TNFRSF4, OX40L receptor, OX40, CD134, ACT35 antigen
计算分子量 29 kDa
GenBank蛋白编号NM_003327
基因名称 CD134
Gene ID (NCBI) 7293
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP43489
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).