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验证数据展示

  • IP experiment of LNCaP using 34104-1-AP (same clone as 34104-1-PBS)

    IP experiment of LNCaP using 34104-1-AP (same clone as 34104-1-PBS)

    IP result of anti-CASD1 (IP:34104-1-AP, 4ug; Detection:34104-1-AP 1:300) with LNCaP cells lysate 1280 ug. This data was developed using the same antibody clone with 34104-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 34104-1-AP (same clone as 34104-1-PBS)

    IHC staining of human breast cancer using 34104-1-AP (same clone as 34104-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 34104-1-AP (CASD1 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 34104-1-PBS in a different storage buffer formulation.

  • IHC staining of human cervical cancer using 34104-1-AP (same clone as 34104-1-PBS)

    IHC staining of human cervical cancer using 34104-1-AP (same clone as 34104-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 34104-1-AP (CASD1 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 34104-1-PBS in a different storage buffer formulation.

CASD1 Polyclonal antibody, PBS Only

CASD1 Polyclonal Antibody for IHC, IP, Indirect ELISA
Cat No. 34104-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IP, Indirect ELISA

别名

C7orf12, CAS1 Domain Containing 1, CAS1 Domain Sialic Acid O Acetyltransferase 1, CAS1 domain-containing protein 1, EC:2.3.1.45

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

34104-1-PBS targets CASD1 in IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag41108

Product name: Recombinant human CASD1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 109-227 aa of BC063284

Sequence: PQFKEEGNKHENIPFEDKTASVKVDFLWHPEVNGSMKQCIKVWTEDSIAKPHVIVAGAATWSIKIHNGSSEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 CAS1 domain containing 1
别名 C7orf12, CAS1 Domain Containing 1, CAS1 Domain Sialic Acid O Acetyltransferase 1, CAS1 domain-containing protein 1, EC:2.3.1.45
观测分子量92 kDa
GenBank蛋白编号BC063284
基因名称 CASD1
Gene ID (NCBI) 64921
RRIDAB_3743153
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ96PB1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CASD1 (CAS1 domain-containing 1) is a multi-pass transmembrane protein localized in the trans-Golgi network. It contains an N-terminal SGNH hydrolase domain and a C-terminal region with 15 transmembrane segments. CASD1 catalyzes the O-acetylation of the C9 position of CMP-sialic acid, generating the 9-O-acetylated CMP-sialic acid donor, which is subsequently used for the synthesis of O-acetylated gangliosides (e.g., 9-O-AcGD3). This modification shields sialic acid from recognition by viral receptors, participates in host-pathogen interactions, and regulates the pro-apoptotic activity of GD3. (PMID: 34208013)

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