验证数据展示
产品信息
22244-1-PBS targets CALCA/Calcitonin in WB, IP, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IP, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag17737 Product name: Recombinant human CALCA protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 65-141 aa of BC093753 Sequence: ELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | Calcitonin |
| 别名 | CALCA, Calcitonin, CALC1, Calcitonin gene-related peptide 1, Calcitonin gene-related peptide I |
| 计算分子量 | 141 aa, 15 kDa |
| 观测分子量 | 14 kDa, 5 kDa |
| GenBank蛋白编号 | BC093753 |
| 基因名称 | CALCA |
| Gene ID (NCBI) | 796 |
| RRID | AB_3669393 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P01258 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Calcitonin is a peptide hormone consisting of 32 amino acids, primarily synthesized by the parafollicular cells (C cells) of the human thyroid gland. It plays a crucial role in regulating calcium levels in the blood by decreasing them. Calcitonin opposes the actions of parathyroid hormone, which increases blood calcium levels. Calcitonin works through a G protein-coupled receptor, known as the calcitonin receptor, which predominantly transmits signals via the cAMP and PLC/IP3 pathways. Its primary physiological effects are on osteoclasts and the tubular epithelium of kidneys.
