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验证数据展示

  • IHC staining of Mouse cerebellum using 86004-1-RR (same clone as 86004-1-PBS)

    IHC staining of Mouse cerebellum using 86004-1-RR (same clone as 86004-1-PBS)

    Immunohistochemical analysis of paraffin-embedded Mouse cerebellum tissue slide using 86004-1-RR (CA8 antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86004-1-PBS in a different storage buffer formulation.

  • IHC staining of Mouse cerebellum using 86004-1-RR (same clone as 86004-1-PBS)

    IHC staining of Mouse cerebellum using 86004-1-RR (same clone as 86004-1-PBS)

    Immunohistochemical analysis of paraffin-embedded Mouse cerebellum tissue slide using 86004-1-RR (CA8 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86004-1-PBS in a different storage buffer formulation.

CA8 Recombinant antibody, PBS Only

CA8 Uni-rAbTM Recombinant Antibody for IHC, Indirect ELISA
Cat No. 86004-1-PBS

产品说明书

CloneNo. 250429B8

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

carbonic anhydrase VIII, CA 8, CA VIII, CALS, Carbonic anhydrase-related protein

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86004-1-PBS targets CA8 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 CA8 fusion protein Ag3068 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 carbonic anhydrase VIII
别名 carbonic anhydrase VIII, CA 8, CA VIII, CALS, Carbonic anhydrase-related protein
计算分子量 290 aa, 32 kDa
GenBank蛋白编号BC015531
基因名称 CA8
Gene ID (NCBI) 767
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP35219
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The CA8 (CARP) gene encodes carbonic anhydrase VIII, which is part of a family of zinc metalloenzyme. CA8 has a central carbonic anhydrase motif, but it lacks carbonic anhydrase activity due to absence of catalytic zinc coordinating residues(PMID:2121526). CARP is a novel IP3R1-binding protein, and is expressed in Purkinje cells abundantly. CA8 is co-localized with IP3R1 in Purkinje cells and it binds to IP3R1, reducing the affinity of the receptor for its ligand, IP3(PMID:12611586). Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3)(PMID:19461874).