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验证数据展示

  • WB analysis of human plasma using 86463-4-RR (same clone as 86463-4-PBS)

    WB analysis of human plasma using 86463-4-RR (same clone as 86463-4-PBS)

    human plasma was subjected to SDS PAGE followed by western blot with 86463-4-RR (Complement C5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86463-4-PBS in a different storage buffer formulation.

  • Affinity of 86463-4-RR

    Affinity of 86463-4-RR

    Biolayer interferometry (BLI) kinetic assays of 86463-4-RR against Human C5a were performed. The affinity constant is 0.251 nM.

C5a Recombinant monoclonal antibody, PBS Only

C5a Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 86463-4-PBS

产品说明书

CloneNo. 251190F4

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

C5, Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, complement component 5, CPAMD4

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86463-4-PBS targets C5a in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg4205

Product name: Recombinant Human Complement C5 protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 678-751 aa of NM_001735.3

Sequence: TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 complement component 5
别名 C5, Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, complement component 5, CPAMD4
计算分子量188 kDa
观测分子量120 kDa
GenBank蛋白编号NM_001735.3
基因名称 C5
Gene ID (NCBI) 727
RRIDAB_3744903
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP01031
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The complement system is an important effector that bridges the innate and adaptive immune systems. The fifth component of complement, C5, is part of the complement cascade and plays an important role in inflammation and cell killing. It consists of disulfide-linked alpha and beta polypeptide chains but can be cleaved into two active peptides (C5a and C5b) by C5 convertases. Mutations and defects in C5 are associated with severe recurrent infections. This antibody specifically recognizes the C5 alpha chain.(PMID: 20010915; PMID: 8011297; PMID: 6554279)

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