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验证数据展示

  • IHC staining of mouse spleen using 84882-5-RR (same clone as 84882-5-PBS)

    IHC staining of mouse spleen using 84882-5-RR (same clone as 84882-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 84882-5-RR (BCL3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84882-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse spleen using 84882-5-RR (same clone as 84882-5-PBS)

    IHC staining of mouse spleen using 84882-5-RR (same clone as 84882-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 84882-5-RR (BCL3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84882-5-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 84882-5-RR (same clone as 84882-5-PBS)

    IF Staining of HeLa using 84882-5-RR (same clone as 84882-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using BCL3 antibody (84882-5-RR, Clone: 242233B11 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84882-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84882-5-RR

    Affinity and Kinetic Characterization of 84882-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84882-5-RR against Human BCL3 were performed. The affinity constant is 0.581 nM.

BCL3 Recombinant monoclonal antibody, PBS Only

BCL3 Uni-rAb® Recombinant Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 84882-5-PBS

产品说明书

CloneNo. 242233B11

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, IF/ICC, Indirect ELISA

别名

242233B11, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84882-5-PBS targets BCL3 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag13375

Product name: Recombinant human BCL3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 97-446 aa of BC064993

Sequence: NLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 B-cell CLL/lymphoma 3
别名 242233B11, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37
计算分子量 446 aa, 47 kDa
观测分子量 48-60 kDa
GenBank蛋白编号BC064993
基因名称 BCL3
Gene ID (NCBI) 602
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP20749
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BCL3 (B-cell lymphoma 3 protein) has seven ankyrin repeat domains, a proline-rich N terminal domain and a serine- and proline-rich C-terminal domain (PMID: 31930327). BCL3 is an important contributor to chronic inflammatory disease states, such as osteoarthritis and rheumatoid arthritis (PMID: 12483727). BCL3 is a predominantly nuclear protein containing a trans-activation domain, and it can be recruited to NF-κB-responsive promoters, resulting in transcriptional activation or repression depending on the subunit composition of NF-κB complexes (PMID: 25089799, PMID: 30135206). BCL3 is known to be overexpressed in human breast cancers and is associated with reduced metastasis-free survival (PMID: 38255248).

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