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验证数据展示

  • WB analysis of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    WB analysis of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 16043-1-AP (BCCIP antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    IP experiment of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    IP result of anti-BCCIP (IP:16043-1-AP, 4ug; Detection:16043-1-AP 1:800) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    IF Staining of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using BCCIP antibody (16043-1-AP) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

BCCIP Polyclonal antibody, PBS Only

BCCIP Polyclonal Antibody for WB, IF/ICC, IP, Indirect ELISA
Cat No. 16043-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, IP, Indirect ELISA

别名

TOK1, TOK 1, Protein TOK-1, Protein TOK 1, P21- and CDK-associated protein 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® BCCIP Ready-To-Use IHC Kit. BCCIP primary antibody included.

产品信息

16043-1-PBS targets BCCIP in WB, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag8934

Product name: Recombinant human BCCIP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-314 aa of BC009771

Sequence: MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAEKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 BRCA2 and CDKN1A interacting protein
别名 TOK1, TOK 1, Protein TOK-1, Protein TOK 1, P21- and CDK-associated protein 1
计算分子量 314 aa, 36 kDa
观测分子量 50-58 kDa
GenBank蛋白编号BC009771
基因名称 BCCIP
Gene ID (NCBI) 56647
RRIDAB_2063712
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9P287
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BCCIP (or TOK1) is isolated as a BRCA2- and CDKN1A (p21)-interacting protein and is implicated in homologous recombination (HR) pathway and inhibition of DNA replication stress. BCCIP is an evolutionarily conserved nuclear protein with multiple interacting domains. BCCIP deficiency in mice impaired embryonic and postnatal neural development, causing severe ataxia, cerebral and cerebellar defects, and microcephaly, which are associated with spontaneous DNA damage and subsequent cell death in the proliferative cell populations of the neural system during embryogenesis. BCCIP is essential for maintaining the transactivation activity of wild type p53 suggesting a potential role of BCCIP in cancer etiology.

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