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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
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验证数据展示

  • WB analysis using 84038-3-RR (same clone as 84038-3-PBS)

    WB analysis using 84038-3-RR (same clone as 84038-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84038-3-RR (BCAM antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84038-3-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 84038-3-RR (same clone as 84038-3-PBS)

    IHC staining of human placenta using 84038-3-RR (same clone as 84038-3-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 84038-3-RR (BCAM antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84038-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84038-3-RR

    Affinity and Kinetic Characterization of 84038-3-RR

    Biolayer interferometry (BLl) kinetic assays of 84038-3-RR against Human BCAM were performed. The affinity constant is 6.16 nM.

BCAM Recombinant antibody, PBS Only

BCAM Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84038-3-PBS

产品说明书

CloneNo. 241051C8

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

241051C8, Auberger B antigen, Basal cell adhesion molecule, B-CAM cell surface glycoprotein, CD239

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

84038-3-PBS targets BCAM in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 BCAM fusion protein Ag28181 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 basal cell adhesion molecule (Lutheran blood group)
别名 241051C8, Auberger B antigen, Basal cell adhesion molecule, B-CAM cell surface glycoprotein, CD239
计算分子量 67 kDa
观测分子量67 kDa, 78-85 kDa
GenBank蛋白编号BC050450
基因名称 BCAM
Gene ID (NCBI) 4059
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP50895
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Basal cell adhesion molecule (Lu/BCAM) is a membrane-bound glycoprotein of the immunoglobulin superfamily (IgSF), functioning as a receptor for the extracellular matrix protein, laminin. BCAM (Lutheran/basal cell-adhesion molecule, a glycoprotein) belongs to the immunoglobulin superfamily which contains both Lu blood group and BCAM tumor-associated antigens. Proteomics analysis suggests that BCAM might be a potential biomarker for pancreatic cancer (PMID: 19199705). BCAM, involved in cell adhesion and migration, can also promote tumor metastasis and has been elucidated to play a functional role in the metastasis of thyroid cancer and gastric cancer (PMID: 10728810, 35941663). De-glycosylated BCAM has a preidicted molecular weight of 67 kDa. Two BCAM glycoprotein (gp) isoforms are present on human RBCs, Lu (85 kDa) and Lu(v13) (78 kDa); they result from the alternative splicing of intron 13 and differ by the lengths of their cytoplasmic domains (PMID: 23160466).