验证数据展示
产品信息
84541-3-PBS targets BAFF in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | FusionProtein 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | tumor necrosis factor (ligand) superfamily, member 13b |
别名 | 242006E4 |
计算分子量 | 34kd |
观测分子量 | 32kd, 17kd |
GenBank蛋白编号 | NM_033622 |
基因名称 | Tnfsf13b |
Gene ID (NCBI) | 24099 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | Q9WU72 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
BAFF (B-cell-activating factor), also called Tnfsf13b (Tumor necrosis factor ligand superfamily member 13B) and CD257, is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in stimulating B- and T-cell function and the regulation of humoral immunity. A third B-cell-specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response (PMID: 12867412). BAFF cleaved into 2 chains: membrane form is 32-35 kDa; soluble form is 17 kDa.