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验证数据展示

  • WB analysis using 87817-1-RR (same clone as 87817-1-PBS)

    WB analysis using 87817-1-RR (same clone as 87817-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87817-1-RR (Ataxin-3/ATXN3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87817-1-PBS in a different storage buffer formulation.

  • WB analysis of MCF-7 using 87817-1-RR (same clone as 87817-1-PBS)

    WB analysis of MCF-7 using 87817-1-RR (same clone as 87817-1-PBS)

    WB result of Ataxin-3/ATXN3 antibody (87817-1-RR; 1:10000; incubated at room temperature for 1.5 hours) with sh-Control and sh-Ataxin-3/ATXN3 transfected MCF-7 cells. This data was developed using the same antibody clone with 87817-1-PBS in a different storage buffer formulation.

  • IHC staining of human bowen disease using 87817-1-RR (same clone as 87817-1-PBS)

    IHC staining of human bowen disease using 87817-1-RR (same clone as 87817-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human bowen disease tissue slide using 87817-1-RR (Ataxin-3/ATXN3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87817-1-PBS in a different storage buffer formulation.

  • Affinity of 87817-1-RR

    Affinity of 87817-1-RR

    Biolayer interferometry (BLI) kinetic assays of 87817-1-RR against Human Ataxin-3/ATXN3 were performed. The affinity constant is below 1 pM.

Ataxin-3/ATXN3 Recombinant monoclonal antibody, PBS Only

Ataxin-3/ATXN3 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 87817-1-PBS

产品说明书

CloneNo. 253467D4

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

ATX3,ATXN3, ATXN3, AT3, ataxin 3, Ataxin-3

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87817-1-PBS targets Ataxin-3/ATXN3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag41832

Product name: Recombinant human MU154079-4 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-361 aa of

Sequence: MSKIKMESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKKHHHHHHHH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 ataxin 3
别名 ATX3,ATXN3, ATXN3, AT3, ataxin 3, Ataxin-3
观测分子量 35-42 kDa
基因名称 ATXN3
Gene ID (NCBI) 4287
RRIDAB_3745767
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP54252
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.

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