验证数据展示
Planning an IHC experiment? We recommend our IHCeasy AXIN2 Ready-To-Use IHC Kit. AXIN2 primary antibody included.
产品信息
67458-1-PBS targets AXIN2 in WB, Indirect ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, rat |
| 免疫原 | AXIN2 fusion protein Ag29291 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | axin 2 |
| 别名 | Axin-2, Axil, axin 2, Axin like protein, Axin-like protein |
| 计算分子量 | 843 aa, 94 kDa |
| 观测分子量 | 100 kDa |
| GenBank蛋白编号 | BC006295 |
| 基因名称 | AXIN2 |
| Gene ID (NCBI) | 8313 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q9Y2T1 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Axis inhibition protein2 (AXIN2), also known as Coductin or Axil, is a multidomain scaffold protein that negatively regulate Wnt signaling. AXIN2 can directly interact with beta-catenin and GSK3B. AXIN2 has a number of phosphorylation sites, and also can undergo poly(ADP-ribosy)lation by tankyrase TNKS and TNKS2. Poly(ADP-ribosy)lated AXIN2 then get unbiquitinated by RNF146 and leads to its degradation and subsequent activation of Wnt signaling. AXIN2 is localized in the cytoplasm and its mutation is involved in colorectal cancer.