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验证数据展示

  • WB analysis of MCF-7 using 25846-1-AP (same clone as 25846-1-PBS)

    WB analysis of MCF-7 using 25846-1-AP (same clone as 25846-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 25846-1-AP (AVEN Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25846-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 25846-1-AP (same clone as 25846-1-PBS)

    IHC staining of human colon using 25846-1-AP (same clone as 25846-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 25846-1-AP (AVEN antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25846-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with AVEN antibody included

AVEN Polyclonal antibody, PBS Only

AVEN Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 25846-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Cell death regulator Aven, PDCD12

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® AVEN Ready-To-Use IHC Kit. AVEN primary antibody included.

产品信息

25846-1-PBS targets AVEN in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag23020

Product name: Recombinant human AVEN protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-362 aa of BC010488

Sequence: MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 apoptosis, caspase activation inhibitor
别名 Cell death regulator Aven, PDCD12
计算分子量 39 kDa
观测分子量 50 kDa
GenBank蛋白编号BC010488
基因名称 AVEN
Gene ID (NCBI) 57099
RRIDAB_2880266
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NQS1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

AVEN (Apoptosis caspase activation inhibitor) is known to play a role in male and female germ cell development. AVEN protein has also been shown to inhibit the mitochondrial apoptosis pathway by binding to and inhibiting the self-association of proapoptotic APAF-1, as well as binding to and enhancing antiapoptotic BCL-xL activity. AVEN has also recently been shown to function as an activator of the cell cycle-regulating ATM kinase in the DNA damage response pathway. Molecular weight of this protein detected by WB is 50 kDa (PMID: 22751129).

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