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验证数据展示

  • WB analysis using 22641-1-AP (same clone as 22641-1-PBS)

    WB analysis using 22641-1-AP (same clone as 22641-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22641-1-AP (ATOX1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22641-1-PBS in a different storage buffer formulation.

  • WB analysis using 22641-1-AP (same clone as 22641-1-PBS)

    WB analysis using 22641-1-AP (same clone as 22641-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22641-1-AP (ATOX1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22641-1-PBS in a different storage buffer formulation.

  • IF Staining of PC-3 using 22641-1-AP (same clone as 22641-1-PBS)

    IF Staining of PC-3 using 22641-1-AP (same clone as 22641-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed PC-3 cells using ATOX1 antibody (22641-1-AP) at dilution of 1:200 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 22641-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate hyperplasia using 22641-1-AP (same clone as 22641-1-PBS)

    IHC staining of human prostate hyperplasia using 22641-1-AP (same clone as 22641-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate hyperplasia tissue slide using 22641-1-AP (ATOX1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22641-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ATOX1 antibody included

ATOX1 Polyclonal antibody, PBS Only

ATOX1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 22641-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

Antioxidant 1, ATOX 1, ATX1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy ATOX1 Ready-To-Use IHC Kit. ATOX1 primary antibody included.

产品信息

22641-1-PBS targets ATOX1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag18460

Product name: Recombinant human ATOX1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-68 aa of BC112248

Sequence: MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ATX1 antioxidant protein 1 homolog (yeast)
别名 Antioxidant 1, ATOX 1, ATX1
计算分子量 68 aa, 8 kDa
观测分子量 7 kDa
GenBank蛋白编号BC112248
基因名称 ATOX1
Gene ID (NCBI) 475
RRIDAB_2879139
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO00244
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Antioxidant 1 (ATOX1) is a copper chaperone to regulate copper homeostasis in cell. In the cytosol, ATOX1 always binds to copper and transfer to ATPase proteins in the trans-Golgi network, thereby promoting copper supply to various copper-dependent oxidereductases matured within the secretory vesicles (PMID: 28294521). Also, the protein could protect cells against oxidative damage and the expression levels of ATOX1 may help to the inflammatory response and antioxidant defense,even to modulate response to the cancer (PMID: 27472369). ATOX1 plays an important role in the physiology of the human central nervous system ,and it's highly expressed in the cerebral cortex and hippocampus (PMID: 30545441). Either cytosol or nucleus location of ATOX1 has been reported in different literations, which may be associated with cell status (PMID: 24445997; 31317143).

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