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验证数据展示

  • IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

    IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

    IHC staining of human breast cancer using 14699-1-AP (same clone as 14699-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 14699-1-AP (same clone as 14699-1-PBS)

    IHC staining of human ovary tumor using 14699-1-AP (same clone as 14699-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 14699-1-AP (ATF7IP antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14699-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

ATF7IP Polyclonal antibody, PBS Only

ATF7IP Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 14699-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, Indirect ELISA

别名

ATF-interacting protein, ATFa-associated modulator, ATF7-interacting protein, ATF7, ATF

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14699-1-PBS targets ATF7IP in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag6341

Product name: Recombinant human ATF7IP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 756-1106 aa of BC063855

Sequence: NTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQVNPQNSKRFFLYMAPRYM

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 activating transcription factor 7 interacting protein
别名 ATF-interacting protein, ATFa-associated modulator, ATF7-interacting protein, ATF7, ATF
计算分子量 137 kDa
GenBank蛋白编号BC063855
基因名称 ATF7IP
Gene ID (NCBI) 55729
RRIDAB_2878074
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6VMQ6
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ATF7IP (Activating Transcription Factor 7 Interacting Protein), also known as MCAF1 (MBD1-containing chromatin-associated factor 1), is a multifunctional scaffold protein that plays a pivotal role in epigenetic regulation and transcriptional control. Functionally, ATF7IP acts as an adaptor that recruits the histone methyltransferase SETDB1 to specific genomic loci, facilitating the deposition of the heterochromatin mark H3K9me3 and silencing target genes, including retrotransposons such as LINE1. This activity is essential for maintaining genomic stability by suppressing transposable element mobilization and preventing DNA damage.

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