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验证数据展示

  • WB analysis using 31206-1-AP (same clone as 31206-1-PBS)

    WB analysis using 31206-1-AP (same clone as 31206-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31206-1-AP (ASCL1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31206-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 31206-1-AP (same clone as 31206-1-PBS)

    IHC staining of mouse brain using 31206-1-AP (same clone as 31206-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 31206-1-AP (ASCL1 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31206-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 31206-1-AP (same clone as 31206-1-PBS)

    IHC staining of mouse brain using 31206-1-AP (same clone as 31206-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 31206-1-AP (ASCL1 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31206-1-PBS in a different storage buffer formulation.

ASCL1 Polyclonal antibody, PBS Only

ASCL1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 31206-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Achaete-scute homolog 1, ASH1, ASH-1, bHLHa46, Class A basic helix-loop-helix protein 46

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

31206-1-PBS targets ASCL1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag35185

Product name: Recombinant human ASCL1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-118 aa of BC003134

Sequence: MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 achaete-scute complex homolog 1 (Drosophila)
别名 Achaete-scute homolog 1, ASH1, ASH-1, bHLHa46, Class A basic helix-loop-helix protein 46
计算分子量 25 kDa
观测分子量25 kDa
GenBank蛋白编号BC003134
基因名称 ASCL1
Gene ID (NCBI) 429
RRIDAB_3669901
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDP50553
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ASCL1 (achaete-scute family bHLH transcription factor 1), also known as ASH1. It is expected to be located in nucleus. Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach. The calculated molecular weight of ASCL1 is 25 kDa.

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