验证数据展示
产品信息
19513-1-AP targets ASAH2-Specific in ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| 别名 | Acylsphingosine deacylase 2, ASAH2, hCD, HNAC1, LCDase, N CDase, NCDase, Neutral ceramidase, Non lysosomal ceramidase |
| 计算分子量 | 86 kDa |
| GenBank蛋白编号 | NM_019893 |
| 基因名称 | ASAH2 |
| Gene ID (NCBI) | 56624 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9NR71 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ASAH2, also named as HNAC1, belongs to the neutral ceramidase family. ASAH2 catalyze the reaction: N-acylsphingosine + H2O = a carboxylate + sphingosine. ASAH2 hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. ASAH2 acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. And ASAH2 acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. ASAH2 is probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.