验证数据展示
产品信息
23908-1-PBS targets ARNTL2 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag21003 Product name: Recombinant human ARNTL2 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 391-578 aa of BC000172 Sequence: SQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | aryl hydrocarbon receptor nuclear translocator-like 2 |
| 别名 | bHLHe6, BMAL2, Brain and muscle ARNT like 2, CLIF, CYCLE like factor |
| 计算分子量 | 636 aa, 71 kDa |
| 观测分子量 | 70 kDa |
| GenBank蛋白编号 | BC000172 |
| 基因名称 | ARNTL2 |
| Gene ID (NCBI) | 56938 |
| RRID | AB_3742097 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen Affinity purified |
| UNIPROT ID | Q8WYA1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator Like 2), also known as BMAL2 (Brain and Muscle ARNT-Like 2), is a core component of the circadian clock genes within the PAS (PER, ARNT, SIM) superfamily (PMID: 27671790). ARNTL2 has also been demonstrated to play an essential role in various tumors, it is associated with poor survival and immune infiltration in clear cell renal cell carcinoma and triple-Negative Breast Cancer (PMID: 34785930). Besides, ARNTL2 has also been found to promote metastasis of colon carcinoma and estrogen Receptor-Negative Breast Cancer (PMID: 27656887).
