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验证数据展示

  • IHC staining of human liver cancer using 25035-1-AP (same clone as 25035-1-PBS)

    IHC staining of human liver cancer using 25035-1-AP (same clone as 25035-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 25035-1-AP (ARMETL1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25035-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse testis using 25035-1-AP (same clone as 25035-1-PBS)

    WB analysis of mouse testis using 25035-1-AP (same clone as 25035-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 25035-1-AP (ARMETL1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25035-1-PBS in a different storage buffer formulation.

CDNF Polyclonal antibody, PBS Only

CDNF Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 25035-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

ARMETL1, ARMET like protein 1, ARMET-like protein 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

25035-1-PBS targets CDNF in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag18972

Product name: Recombinant human ARMETL1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 103-187 aa of BC133042

Sequence: MSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAATHPKTEL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 arginine-rich, mutated in early stage tumors-like 1
别名 ARMETL1, ARMET like protein 1, ARMET-like protein 1
计算分子量 187 aa, 21 kDa
观测分子量 21 kDa
GenBank蛋白编号BC133042
基因名称 ARMETL1
Gene ID (NCBI) 441549
RRIDAB_2879861
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ49AH0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cerebral dopamine neurotrophic factor (CDNF) is a secreted protein belonging to the mesencephalic astrocyte-derived neurotrophic factor (MANF) family. Unlike classical neurotrophic factors, CDNF is primarily localized in the endoplasmic reticulum and exerts neuroprotective effects through modulating the unfolded protein response (UPR). CDNF has demonstrated potent protective effects on dopaminergic neurons in preclinical models of Parkinson's disease (PD), reducing neuroinflammation and alpha-synuclein aggregation. Its unique mechanism-targeting ER stress rather than receptor tyrosine kinases-offers a promising therapeutic avenue for neurodegenerative disorders. Clinical trials are currently evaluating recombinant human CDNF as a disease-modifying therapy for PD (PMID: 34284712; 37555005; 38290651).

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