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验证数据展示

  • WB analysis of fetal human brain using 87113-1-RR (same clone as 87113-1-PBS)

    WB analysis of fetal human brain using 87113-1-RR (same clone as 87113-1-PBS)

    fetal human brain tissue were subjected to SDS PAGE followed by western blot with 87113-1-RR (APLP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87113-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 87113-1-RR (same clone as 87113-1-PBS)

    IHC staining of mouse brain using 87113-1-RR (same clone as 87113-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 87113-1-RR (APLP1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87113-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 87113-1-RR (same clone as 87113-1-PBS)

    IHC staining of mouse brain using 87113-1-RR (same clone as 87113-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 87113-1-RR (APLP1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87113-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 87113-1-RR (same clone as 87113-1-PBS)

    IF Staining of mouse brain using 87113-1-RR (same clone as 87113-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using APLP1 antibody (87113-1-RR, Clone: 252210C4 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87113-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 87113-1-RR

    Affinity and Kinetic Characterization of 87113-1-RR

    Biolayer interferometry (BLl) kinetic assays of 87113-1-RR against Human APLP1 were performed. The affinity constant is below 1 pM.

APLP1 Recombinant monoclonal antibody, PBS Only

APLP1 Uni-rAb® Recombinant Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 87113-1-PBS

产品说明书

CloneNo. 252210C4

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF-P, Indirect ELISA

别名

A4, Amyloid beta, Amyloid beta precursor like protein 1, Amyloid like protein 1, Amyloid-like protein 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87113-1-PBS targets APLP1 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Eg5634

Product name: Recombinant Human APLP1 protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 39-580 aa of NM_005166.4

Sequence: SLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSRE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 amyloid beta (A4) precursor-like protein 1
别名 A4, Amyloid beta, Amyloid beta precursor like protein 1, Amyloid like protein 1, Amyloid-like protein 1
计算分子量72 kDa
观测分子量80 kDa
GenBank蛋白编号NM_005166.4
基因名称 APLP1
Gene ID (NCBI) 333
RRIDAB_3745348
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP51693-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

APLP1 (Amyloid Precursor-Like Protein 1) is a member of the amyloid precursor protein (APP) family, which also includes APP and APLP2. It is a type I transmembrane glycoprotein that is highly and predominantly expressed in the central nervous system, especially at the postsynaptic density of neurons. Functionally, APLP1 plays important roles in synaptic adhesion, synaptogenesis, and neurite outgrowth. It can form homophilic trans-interactions between neighboring cells, contributing to cell-cell adhesion and the formation of synaptic structures. Its proteolytic processing by α-, β-, and γ-secretases releases intracellular fragments that may participate in transcriptional regulation and signal transduction, potentially influencing gene expression and neuronal survival.

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