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验证数据展示

  • WB analysis of mouse brain using 12305-2-AP (same clone as 12305-2-PBS)

    WB analysis of mouse brain using 12305-2-AP (same clone as 12305-2-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 12305-2-AP (APLP1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12305-2-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 12305-2-AP (same clone as 12305-2-PBS)

    IP experiment of mouse brain using 12305-2-AP (same clone as 12305-2-PBS)

    IP result of anti-APLP1 (IP:12305-2-AP, 4ug; Detection:12305-2-AP 1:600) with mouse brain tissue lysate 3160 ug. This data was developed using the same antibody clone with 12305-2-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 12305-2-AP (same clone as 12305-2-PBS)

    IHC staining of human brain using 12305-2-AP (same clone as 12305-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 12305-2-AP (APLP1 Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 12305-2-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 12305-2-AP (same clone as 12305-2-PBS)

    IHC staining of human brain using 12305-2-AP (same clone as 12305-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 12305-2-AP (APLP1 Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 12305-2-PBS in a different storage buffer formulation.

APLP1 Polyclonal antibody, PBS Only

APLP1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 12305-2-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

A4, Amyloid beta, Amyloid beta precursor like protein 1, Amyloid like protein 1, Amyloid-like protein 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12305-2-PBS targets APLP1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag2951

Product name: Recombinant human APLP1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 55-341 aa of BC012889

Sequence: QVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 amyloid beta (A4) precursor-like protein 1
别名 A4, Amyloid beta, Amyloid beta precursor like protein 1, Amyloid like protein 1, Amyloid-like protein 1
计算分子量 650 aa, 72 kDa
观测分子量 72 kDa
GenBank蛋白编号BC012889
基因名称 APLP1
Gene ID (NCBI) 333
RRIDAB_2056369
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP51693
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

APLP1 (Amyloid Precursor-Like Protein 1) is a member of the amyloid precursor protein (APP) family, which also includes APP and APLP2. It is a type I transmembrane glycoprotein that is highly and predominantly expressed in the central nervous system, especially at the postsynaptic density of neurons. Functionally, APLP1 plays important roles in synaptic adhesion, synaptogenesis, and neurite outgrowth. It can form homophilic trans-interactions between neighboring cells, contributing to cell-cell adhesion and the formation of synaptic structures. Its proteolytic processing by α-, β-, and γ-secretases releases intracellular fragments that may participate in transcriptional regulation and signal transduction, potentially influencing gene expression and neuronal survival.

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