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验证数据展示

  • WB analysis using 11643-1-AP (same clone as 11643-1-PBS)

    WB analysis using 11643-1-AP (same clone as 11643-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11643-1-AP (APH1A antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11643-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 11643-1-AP (same clone as 11643-1-PBS)

    IHC staining of human stomach using 11643-1-AP (same clone as 11643-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 11643-1-AP (APH1A antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11643-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 11643-1-AP (same clone as 11643-1-PBS)

    IHC staining of human stomach using 11643-1-AP (same clone as 11643-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 11643-1-AP (APH1A antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11643-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 11643-1-AP (same clone as 11643-1-PBS)

    IP experiment of HeLa using 11643-1-AP (same clone as 11643-1-PBS)

    IP result of anti-APH1A (IP:11643-1-AP, 4ug; Detection:11643-1-AP 1:4000) with HeLa cells lysate 1600 ug. This data was developed using the same antibody clone with 11643-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 11643-1-AP (same clone as 11643-1-PBS)

    IF Staining of HeLa using 11643-1-AP (same clone as 11643-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using APH1A antibody (11643-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 11643-1-PBS in a different storage buffer formulation.

APH1A Polyclonal antibody, PBS Only

APH1A Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 11643-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

APH 1A, Aph 1alpha, APH-1a, Aph-1alpha, CGI 78

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

11643-1-PBS targets APH1A in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2238

Product name: Recombinant human APH1A protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-265 aa of BC015568

Sequence: MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 anterior pharynx defective 1 homolog A (C. elegans)
别名 APH 1A, Aph 1alpha, APH-1a, Aph-1alpha, CGI 78
计算分子量 265 aa, 29 kDa
观测分子量27-32 kDa
GenBank蛋白编号BC015568
基因名称 APH1A
Gene ID (NCBI) 51107
RRIDAB_2242861
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96BI3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

APH1A is a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease.

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