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验证数据展示

  • WB analysis using 29864-1-AP (same clone as 29864-1-PBS)

    WB analysis using 29864-1-AP (same clone as 29864-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29864-1-AP (ADRB2 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29864-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse stomach using 29864-1-AP (same clone as 29864-1-PBS)

    IF Staining of mouse stomach using 29864-1-AP (same clone as 29864-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse stomach tissue using ADRB2 antibody (29864-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29864-1-PBS in a different storage buffer formulation.

ADRB2 Polyclonal antibody, PBS Only

ADRB2 Polyclonal Antibody for WB, IF-P, Indirect ELISA
Cat No. 29864-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF-P, Indirect ELISA

别名

ADRB2R, ADRBR, B2AR, BAR, Beta 2 adrenergic receptor

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

29864-1-PBS targets ADRB2 in WB, IF-P, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF-P, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag32313

Product name: Recombinant human ADRB2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 330-413 aa of BC012481

Sequence: PDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSPGRNCSTNDSLL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 adrenergic, beta-2-, receptor, surface
别名 ADRB2R, ADRBR, B2AR, BAR, Beta 2 adrenergic receptor
计算分子量46 kDa
观测分子量46-48 kDa
GenBank蛋白编号BC012481
基因名称 ADRB2
Gene ID (NCBI) 154
RRIDAB_2923616
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP07550
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Beta-2 adrenergic receptor (ADRB2), a member of the G protein-coupled receptor (GPCR) family, binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADRB2 is directly linked to one of its final effectors, the class C L-type Ca2+ channel, Cav1.2 (PMID: 11441182). This receptor-channel complex also contains a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase (PKA), and a counteracting phosphatase, PP2A. Different polymorphic forms, point mutations, and/or downregulation of the gene of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes. This antibody detects ADRB2 with a molecular weight of 46-48 kDa, as has been shown by some researches (PMID: 30542705; 35075132).

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