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验证数据展示

  • IP experiment of U2OS using 17860-1-AP (same clone as 17860-1-PBS)

    IP experiment of U2OS using 17860-1-AP (same clone as 17860-1-PBS)

    IP result of anti-ADNP2 (IP:17860-1-AP, 4ug; Detection:17860-1-AP 1:600) with U2OS cells lysate 760 ug. This data was developed using the same antibody clone with 17860-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 17860-1-AP (same clone as 17860-1-PBS)

    IF Staining of U2OS using 17860-1-AP (same clone as 17860-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using ADNP2 antibody (17860-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-phalloidin (red). This data was developed using the same antibody clone with 17860-1-PBS in a different storage buffer formulation.

ADNP2 Polyclonal antibody, PBS Only

ADNP2 Polyclonal Antibody for IF/ICC, IP, Indirect ELISA
Cat No. 17860-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, IP, Indirect ELISA

别名

Activity-dependent neuroprotector homeobox protein 2, ADNP 2, KIAA0863, ZNF508

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17860-1-PBS targets ADNP2 in IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag12327

Product name: Recombinant human ADNP2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 784-1132 aa of BC071589

Sequence: GLSEHSRNRHLGKKKLPMDYSNRGFQLDVDANGNLLFPHLDFITILPKEKLGEREVYLAILAGIHSKSLVPVYVKVRPQAEGTPGSTGKRVSTCPFCFGPFVTTEAYELHLKERHHIMPTVHTVLKSPAFKCIHCCGVYTGNMTLAAIAVHLVRCRSAPKDSSSDLQAQPGFIHNSELLLVSGEVMHDSSFSVKRKLPDGHLGAEDQRHGEEQPPILNADAAPGPEKVTSVVPFKRQRNESRTEGPIVKDEALQILALDPKKYEGRSYEEKKQFLKDYFHKKPYPSKKEIELLSSLFWVWKIDVASFFGKRRYICMKAIKNHKPSVLLGFDMSELKNVKHRLNFEYEP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ADNP homeobox 2
别名 Activity-dependent neuroprotector homeobox protein 2, ADNP 2, KIAA0863, ZNF508
计算分子量 1131 aa, 123 kDa
观测分子量123 kDa
GenBank蛋白编号BC071589
基因名称 ADNP2
Gene ID (NCBI) 22850
RRIDAB_3741938
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6IQ32
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Activity-dependent neuroprotective protein (ADNP) 2 (KIAA0863; ZNF508) gene, a homeobox-profile containing gene, was identified in a screen for homologous proteins to ADNP. The human ADNP2 contains 1131 amino acid residues with a molecular weight of 122.8 KDa. During development, a relatively high level of ADNP2 gene expression was found in the embryonic mouse brain and was sustained throughout embryogenesis and adulthood. Activity-dependent neuroprotective protein (ADNP), an early marker essential for brain formation, interacts with microtubule end-binding proteins (EB1, EB2, and EB3). EB1 and EB3 are highly expressed in neurons (axons and dendritic spines, respectively) and EB1 enhancement of neurite outgrowth is attenuated by EB2. (PMID: 26315608, PMID: 18179478)

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