ADAM12 Polyclonal antibody

ADAM12 Polyclonal Antibody for ELISA
Cat No. 26928-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

ELISA

ADAM 12, Disintegrin and metalloproteinase domain-containing protein 12, EC:3.4.24.-, MCMP, Meltrin-alpha

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
规格: 

-/ -


产品信息

26928-1-AP targets ADAM12 in ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 ADAM12 fusion protein Ag17474 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ADAM metallopeptidase domain 12
别名 ADAM 12, Disintegrin and metalloproteinase domain-containing protein 12, EC:3.4.24.-, MCMP, Meltrin-alpha
计算分子量 909 aa, 100 kDa
观测分子量 68 kDa
GenBank蛋白编号BC060804
基因名称 ADAM12
Gene ID (NCBI) 8038
RRIDAB_2880689
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO43184
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

ADAM12, also named as MLTN and Meltrin-alpha, is involved in skeletal muscle regeneration, specifically at the onset of cell fusion. It is also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. ADAM12 is expressed in human malignant tumors. It is involved in the regulation of growth factor activities and integrin functions, leading to promotion of cell growth and invasion, although the precise mechanisms of these are not clear at the present time.(PMID:17355265) ADAM12's ability to degrade extracellular matrix components likely allows it to detach cancer cells from the basement membrane and assist them on their route to metastasis. But the protein's role not just as a biomarker of breast cancer but as a gateway to cancer cell migration is only now being understood. ADAM12 has 2 isoforms with the calculated molecular mass of 100 and 80 kDa, and this antibody can recognize all isoforms of ADAM12. ADAM12 has 4 forms: 120kd full-length form, 90 kDa mature (processed form that lack the prodomain), 50-68 kDa degradation product and 27 kDa prodomain.

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