Recombinant Human SERPING1/C1 Inhibitor protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human SERPING1 protein Asn23-Ala500 (Accession# P05155-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 710 |
| 蛋白编号 | P05155-1 |
| 预测分子量 | 78.4 kDa |
| SDS-PAGE | 100-135 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
SERPING1, also known as C1 Inhibitor (C1INH), is a member of the Serine proteinase inhibitor family. Its main function is the inhibition of the complement system to prevent spontaneous activation. It inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE).
参考文献:
1. Cugno, Massimo et al. Trends in molecular medicine vol. 15,2 (2009): 69-78. 2. Haslund, Didde et al. The Journal of clinical investigation vol. 129,1 (2019): 388-405. 3. Ryø, Laura Barrett et al. The Journal of allergy and clinical immunology vol. 152,5 (2023): 1218-1236.e9.
