Recombinant Rat Clusterin protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat Clusterin protein Glu22-Glu447 (Accession# P05371) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 24854 |
| 蛋白编号 | P05371 |
| 预测分子量 | 74.7 kDa |
| SDS-PAGE | 27-33 kDa, 58-70 kDa and 85-95 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Clusterin (also known as apolipoprotein J) is a 75-80 kDa heterodimeric glycoprotein produced by a wide array of tissues and found in most biological fluids. It is encoded by one single gene and cleaved posttranslationally into α and β subunits prior to secretion from the cell. Many functions have been described for clusterin, including regulating apoptosis, transporting lipids, controlling cell interactions, and regulating complement. Increased plasma clusterin levels have been associated with the severity, pathology, and progression of Alzheimer's disease.
参考文献:
1. Rosenberg, M E, and J Silkensen. The international journal of biochemistry & cell biology vol. 27,7 (1995): 633-45. 2. Wilson, M R, and S B Easterbrook-Smith. Trends in biochemical sciences vol. 25,3 (2000): 95-8. 3. Jones, Steve E, and Catherine Jomary. The international journal of biochemistry & cell biology vol. 34,5 (2002): 427-31. 4. Thambisetty, Madhav et al. Archives of general psychiatry vol. 67,7 (2010): 739-48. 5. Schrijvers, Elisabeth M C et al. JAMA vol. 305,13 (2011): 1322-6.
