Recombinant Mouse Epha2 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Epha2 protein Lys26-Val538 (Accession# Q03145) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 13836 |
| 蛋白编号 | Q03145 |
| 预测分子量 | 82.4 kDa |
| SDS-PAGE | kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
EPHA2 (Eph receptor A2) is a type I single-transmembrane protein belonging to the Ephrin receptor subfamily of the receptor tyrosine kinase (RTK) family. This protein consists of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular kinase domain, and is widely expressed on the surface of epithelial cells, endothelial cells, and various tumor cells. Under physiological conditions, EPHA2 participates in cell migration, adhesion, angiogenesis, and tissue boundary formation by binding to its ligands, such as Ephrin-A1. Under pathological conditions, abnormalities in the Epha2 signaling pathway are closely related to tumor progression, metastasis, and drug resistance.
参考文献:
1. Irie, Naoko et al. The Journal of biological chemistry vol. 284,21 (2009): 14637-44. 2. Guo, Hong et al. Cancer research vol. 66,14 (2006): 7050-8. 3. Brantley-Sieders, Dana M et al. Journal of cell science vol. 117,Pt 10 (2004): 2037-49.
