Recombinant Human ROBO4 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human ROBO4 protein Gln28-Arg467 (Accession# Q8WZ75-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 54538 |
| 蛋白编号 | Q8WZ75-1 |
| 预测分子量 | 73.1 kDa |
| SDS-PAGE | 75-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ROBO4 belongs to the immunoglobulin superfamily and ROBO family. It is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. It’s reported that activating Robo4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.
参考文献:
1. Jones, Christopher A et al. Nature medicine vol. 14,4 (2008): 448-53. 2. Dai, Chang et al.Bioscience reports vol. 39,7 (2019): null. 3.Xiao W,Pinilla-Baquero A,Faulkner J, et al.Sci Rep. 2022;12 (1):4352.
